On Jan 26, 2018 12:32 AM Ajtorres12 wrote:
Anybody have info on jak2 positive mutation. With low platlet counts and low (within standard range) rbc and wbc and hemoglibin hermatacrit values. Im waiting on a bone marrow biopsy results. Possible PV??? Why the low counts if the bone marrow is always "on"???
Looking only at what you mentioned it seems PV doesn't fit the whole picture... mutations per se are not deterministic to any symptoms. That's why FDA banned (in the US) most DNA testing that indicated "you will (likely) get cancer", since many people looking at those tests start panicking and they were still alive no matter what the tests said.
In a general way, cancers require at least 2 genetic cloning failures: one that supresses normal growth control, and one that supresses anti-abnormal growth controls. This belts & suspenders approach is what keeps most of the population from dying of cancer, while keeping human beings evolving by adding mutations that are sometimes beneficial.