Anyone used 3bp (3-bromopyruvate)?

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RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Thu Feb 04, 2021 01:43 AM

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HI J, 

That is great! I hope that means you will be active again in doing reserch and bring back your enthusiasm here and/or on the Blog :)

Kind regards,
Daniel

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Feb 04, 2021 02:10 AM

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Thank you, D. I really appreciate your comment.

You know that I want to get back and do my best to help others. It is so difficult when family are trying to help their loved ones with cancer. There is so much research out there and it is difficult to make sense of it. Typically patients and their families are completely lost.

Your blog and this thread can helpf them and give a coherent way of understanding cancer from the metabolic perspective. After all of these years it has become clear that there is substantial treatment potential using the metabolic approach. However, it is frustrating that a truly overwhelming anti-cancer effect still eludes us. If cancer could be metabolically stressed in the right combination, then a near total implosion of the cancer mass seems highly plausible. We keep on searching.

One memorable example of tumor collapse was with the melanoma patient. 3-BP and paracetamol was extremely effective. It is always exciting waiting to see more examples like that. 

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Feb 04, 2021 02:29 AM

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In terms of my health problems, when the doctor asked me where it hurted I had to admit it was Everywhere! Strange thing was there was no treatment for everywhere. The idea there was a limit of one region of pain for each visit. The first place to start was the inhaler. I gave up after that because I suppose that there would be one medicine for every other part of my body. Basically i would need a suitcase of pills.

The funny thing was the hydrogen machine seems to have helped remove the pain: Everywhere. Breathing is only somewhat better, but the pain has almost disappeared. Since this is hydrogen and hydrogen is an anti-oxidant I am guessing the problem was widespread inflammation. Not sure what the inflammation was related to, though even as a symptomatic treatment it feels great. I am going to have these machines running most of the day. Only limitation might be how much water I can boil.

I had wondered whether nano-fuel cells might have some anti-cancer potential. Yet, these hydrogen makers, probably are reverse fuel cells: Give them water and electricity and they will give you hydrogen and oxygen. 

D, your enquiries got me motivated to take action. Probably without some nagging I would just let it roll forward. I now have an entire pharmacy of anti-inflammatories en route. today I got another hydrogen maker. This one is one of those thermos sized hydorgen makers. The other one I received had a nose unit, so I could also inhale the hydrogen. The retailers seem to be dumping these first generation units because the next generation of even higher ppm are now rolling out. Some of them have A LOT of hyrogen production.

I am now also waiting on liquid NAC and liquid glutathione. I am looking forward to swallowing some liquid anti-oxidants. If I have some sort of throat inflammation (which it feels like I have) then these free radicals wouldn't have a chance with these powerful liquid formulations. I was also able to find a good price for these products as well.

Of course, the truly amusing part of all of this is that hydrogen therapy actually seems to be another metabolic cancer therapy. It really is almost too much to believe at times. Anything that is involved with fundamental biology seems to always be related to metabolics. Hydrogen is centrally related to OXPHOS. You start to wonder how Co2 might fit from the metabolic angle.

If I can maintain this recovery, then I can return to being active on forum again. Yeah! 

     

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Thu Feb 04, 2021 02:46 AM

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D have you heard of any cancer clinics that are using hydrogen therapy? These generators have been quite popular for quite some time now, though my posts on your blog about this noted that the high end models which hadLARGEhydrogen  production cost ~$1,000 plus. These were in the 500,000 ppm range and the consumer grade (cheap) models are in the ~up to 5,000 ppm range (Fifth Generation).

There does seem to be some complexity involved as you do not always want ant-oxidant treatment alongside others (e.g., high dose Vitamin C). Nevertheless, in a well-considered combination hydrogen could be beneficial.

Really glad that the Compass is back! Perhaps the sign in screening deterred too many posters and/or visitors.   

RE: Anyone used 3bp (3-bromopyruvate)?

by slate on Thu Feb 04, 2021 06:04 AM

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hi jcancom & daniel been following 3BP thread for 2 or 3 years from australia now,hadn't heard anything for ages thought it had been closed down or something.good to read what you are up to(i don't understand too much)but trying to read between the lines.whet ever happened to those trials with 3BP in germany where some people died,never haerd what the outcome was.cheers and keep posting

RE: Anyone used 3bp (3-bromopyruvate)?

by Jcancom on Sat Feb 06, 2021 01:33 AM

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slate, thank you for commenting and thank you for asking about the clinic tragedy.

To clarify the treatment at the clinic with the tragedy was not within the context of a clinical trial, but under a uniquely German form of alternative medicine.

As far as I am aware the report from the tragedy has never been published. In July of 2019 the clinic founder was found guilty of overdosing the patients with 3-BP. This helped to provide an explanation for what was an unexpected response to 3-BP.

From what we currently understand about metabolic approaches to cancer, extending dosing of 3-BP past the safety line is not necessary. Everyone can become so desperate with cancer that assuming unneeded risk might appear to be justifiable. Yet, from our ongoing investigation into metabolics, what has emerged is the near universal presence of potential amplifers. This amplifers can potentiate treatment effects, while reducing risk.

The non-publication of the actual report was quite surprising. They seemed to be all ready to release it a few years ago, but then appeared to decide not to publish it at all. It does give it a feel of a coverup. The lurking question that has yet to be resolved is whether the tragedy was caused because 3-BP worked too well (i.e., tumor lysis syndrome). If it were TLS, then there would have been potential treatment options; yet, without the report this remains an open question.

For me, it continues to be difficult to understand how after more than 20 years a cancer treatment as powerful as 3-BP has yet to start a clinical trial. One could imagine that with selection one could have one 3-BP super-responder after another. The naysayers would need to quickly stop naysaying.

Best Wishes, J 

RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Tue Feb 09, 2021 11:46 PM

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On Feb 04, 2021 2:46 AM Jcancom wrote:

D have you heard of any cancer clinics that are using hydrogen therapy? These generators have been quite popular for quite some time now, though my posts on your blog about this noted that the high end models which hadLARGEhydrogen  production cost ~$1,000 plus. These were in the 500,000 ppm range and the consumer grade (cheap) models are in the ~up to 5,000 ppm range (Fifth Generation).

There does seem to be some complexity involved as you do not always want ant-oxidant treatment alongside others (e.g., high dose Vitamin C). Nevertheless, in a well-considered combination hydrogen could be beneficial.

Really glad that the Compass is back! Perhaps the sign in screening deterred too many posters and/or visitors.   

Hi J, I dont know any specific clinic speciliazed in hydrogen therapy.

RE: Anyone used 3bp (3-bromopyruvate)?

by Danielus on Wed Feb 10, 2021 12:04 AM

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On Feb 04, 2021 6:04 AM slate wrote:

hi jcancom & daniel been following 3BP thread for 2 or 3 years from australia now,hadn't heard anything for ages thought it had been closed down or something.good "" target="_blank" rel="nofollow">http://something.good " target="_blank" rel="nofollow">something.good to read what you are up to(i don't understand too much)but trying to read between the lines.whet "" target="_blank" rel="nofollow">http://lines.whet " target="_blank" rel="nofollow">lines.whet ever happened to those trials with 3BP in germany where some people died,never haerd what the outcome was.cheers "" target="_blank" rel="nofollow">http://was.cheers " target="_blank" rel="nofollow">was.cheers and keep posting

Indeed, the conclusion was that the naturophat used much higer doses of 3BP (it was somwhere between 5x and 10x as I remember) larger than the dose used in humans before with no issue. I myself used intravenous 3BP for more than a year at the known suitable dose withouth side effects. Evering water used at 5x-10x higer than the indicated daily amount we shoudl drink could be at least dangerous. 

RE: Anyone used 3bp (3-bromopyruvate)?

by dumbcritic on Fri Feb 19, 2021 02:40 AM

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A new company, who will be in the clinic soon https://penrosetherapeutx.com/science-and-pipeline/

RE: Anyone used 3bp (3-bromopyruvate)?

by dumbcritic on Sat Feb 20, 2021 10:40 PM

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Vidac Pharma has announced the inclusion of the first patient in a placebo controlled PhII trial for early forms of CTCL treated with its first-in-class drug VDA-1102. This disrupts the binding of HK2 from VDAC. 

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